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PBMC Donor Program: Donor Profile

Fred Hutch is a world leader in cancer and disease research. Located in Seattle, Washington, a global nexus of scientific and technical innovation, our work is at the center of better treatments, better outcomes, and longer lives around the world. We believe every win is a win for all- that working together is the fastest way to discover cures and honor the courage of patients, the compassion of caregivers, and the belief in a disease-free future.

There are several reasons why the Center needs to acquire large numbers of peripheral blood mononuclear cells for research studies. First, hematopoietic stem cells collected from the peripheral blood (PBSC) by leukapheresis have been used successfully for autologous, syngeneic, and allogeneic transplantation at this center. The use of PBSC as the source of cells for transplantation continues to expand both in terms of numbers of patients as well as in numbers of protocols. Laboratory evaluation and development of novel PBSC processing techniques requires full-scale access to these types of cells, in quantities which are too large to be obtained as research samples derived from PBSC collections intended for transplantation. Second, large cell numbers are required for certain experimental models, for example the introduction of purified human stem cells into SCID mice. Third, mononuclear cells are needed as feeder layers for the generation of antigenspecific T-cell populations. Fourth, large cell numbers are needed to optimize ex-vivo expansion and gene therapy protocols. For each of these types of research, along with other future applications, these larger cell quantities can only be obtained from volunteer donors where the entire product can be used in the research effort. This protocol has been designed to allow for the collection of these cells for researchers at this Center, as well as for outside institutions.

Thank you for your interest expressed in our donor program and cause! We are always seeking Peripheral Blood Mononuclear Cells (PBMC) and Peripheral Blood Stem Cells (PBSC) Donors. There are two types of donations scheduled through the PBMC donor program: mobilized and non-mobilized.

A mobilized donation consists of 6 appointments total, including a pre-screening appointment, 4 to 5 G-CSF appointments (30 min/each), and 1 or 2 donation appointments (4 to 6 hours each). G-CSF (growth factor) is administered prior to donation in order to stimulate the bone marrow to produce hematopoietic stem cells for the days of donation. The donation appointments are scheduled on two consecutive days.

A typical Mobilized donation appointment set requires an extensive time commitment as the below example shows*:

Appointment Date	Appointment Time	Appointment Type	Required Time	Where
TBD**	TBD Mon.-Fri. (8:00 AM-4:00 PM) (1 week prior to donation)	Registration	10 minutes	FHCC Clinic Bldg 1, 1^st Floor, Registration
TBD**	TBD Mon.-Fri. (8:00 AM-4:00 PM) (1 week prior to donation)	Pre-screening	1.5 hours	FHCC Clinic Bldg 1, 5^th Floor, Apheresis
Friday	TBD (arranged at pre-screening)	GCSF injection	30 minutes	FHCC Clinic Bldg 1, 5^th Floor, Apheresis
Saturday	TBD (arranged at pre-screening)	GCSF injection	30 minutes	FHCC Clinic Bldg 1 6^th Floor, BMT
Sunday	TBD (arranged at pre-screening)	GCSF injection	30 minutes	FHCC Clinic Bldg 1 6^th Floor, BMT
Monday	7:30 AM	GCSF injection+ Donation	4 - 6 hours	FHCC Clinic Bldg 1, 5^th Floor, Apheresis
Tuesday	7:30 AM	Donation	4 - 6 hours	FHCC Clinic Bldg 1, 5^th Floor, Apheresis

* mobilized donations may instead consist of 5 GCSF injections and a single donation date

**same date

A non-mobilized donation consists of two appointments, a pre-screening appointment and a donation appointment. No additional procedures are required prior to donation.

A typical non-mobilized (research/clinical) donation schedule:

Appointment Date	Appointment Time	Appointment Type	Required Time	Where
TBD*	TBD Mon.-Fri. (8:00 AM-4:00 PM) (1 week prior to donation)	Registration	10 minutes	FHCC Clinic Bldg 1, 1^st Floor, Registration
TBD*	TBD Mon.-Fri. (8:00 AM-4:00 PM) (1 week prior to donation)	Pre-screening	1 hour	FHCC Clinic Bldg 1, 5^th Floor, Apheresis
TBD	7:30 AM	Donation	3 - 4 hours	FHCC Clinic Bldg 1, 5^th Floor, Apheresis

*same date

Below are examples of documents used during the donation process, including the pre-screening questionnaire, clinical questionnaire, clinical medications list, and donor consents. These documents can also be found on the CCEH Apheresis Donor Program website.

Please complete the survey below.

If you are having trouble submitting the form, please make sure all required fields are filled in with the appropriate information. You will receive a confirmation email once your donor profile has been successfully submitted. Only one survey is required per donor. Once you've submitted your profile, you will be added to our permanent database.

First Name

* must provide value

Middle Name

Last Name

* must provide value

Preferred Type of Donation

* must provide value

Please note that donors may not complete more than one profile.

If you are receiving an error message then there is already a profile associated with your email address on file.

Completed profiles are stored in our online database and do not expire. It may take an extended period of time until you are contacted for a donation due to the level of interest in our donation program.

If you have already completed a donor profile and would like to make a change, please email PBMC.DonorProgram@fredhutch.org for assistance.

Email Address

* must provide value

Emailed appointments with no response/availability...

reset

Phone Number

* must provide value

Street Address

* must provide value

City

* must provide value

State

* must provide value

Please be aware all donations with the Heimfeld Donor Program must take place in Seattle, Washington.

Would you like to continue with your donor profile?

Yes

reset

Please specify state

Zip Code

* must provide value

Date of Birth

* must provide value

Blood type

Race/Ethnicity

Hispanic/
Latino

American Indian/
Alaska Native

Asian

Black

Pacific
Islander

White

Other/Do Not Report

Ethnicity

Hispanic or Latino

Not Hispanic or Latino

Decline to Report

Race

American Indian or Alaska Native

Asian

Black or African American

Native Hawaiian or Pacific Islander

White

Other/Do Not Report

Are you available on short notice for appointment sets and schedules?

Yes

reset

Questions/Comments

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I have read the pre-screening questionnaire and consent forms and feel I qualify based on the material provided.

* must provide value

Yes

reset

I feel comfortable with the donation process, including the leukapheresis procedure and any additional required procedures, which may or may not include: G-CSF shots, blood draws, virology testing, etc.

* must provide value

Yes

reset

Please type your initials to sign this form.

* must provide value

You have selected an option that triggers this survey to end right now.

To save your responses and end the survey, click the 'End Survey' button below. If you have selected the wrong option by accident and/or wish to return to the survey, click the 'Return and Edit Response' button.